Programmed neurite degeneration in human central nervous system neurons driven by changes in NAD+ metabolism
Abstract Neurite degeneration (ND) precedes cell death in many neurodegenerative diseases.However, it remains unclear how this compartmentalized cell death process is orchestrated in the central nervous system (CNS).The establishment of a CNS axotomy model (using modified 3D LUHMES cultures) allowed us to study metabolic control of ND in human midb